Chinese professional refrigerant inventor and leader  |  CH / EN


Since 1994, we have been focusing on cooling agent anticorrosion and rust prevention for 30 years.


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  • Categories:CLIENTS
  • Time of issue:2019-12-09 00:00:00
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Columbine is a highly specialized and innovative pharmaceutical group with annual sales revenue exceeding 40 billion yuan, including Sichuan Columbine Pharmaceutical Co., Ltd., Sichuan Columbine Pharmaceutical Research Institute Co., Ltd., Klus Pharma Inc. Lun KAZ Pharmaceutical Co., Ltd. (Kazakhstan Cologne), Sichuan Cologne Pharmaceutical Trading Co., Ltd. and more than 100 companies at home and abroad. In 2017, Columbine ranked 155th in China's top 500 manufacturing industries, and its comprehensive strength entered the top three of China's pharmaceutical industry. In 2018, Columbine was awarded as a single champion model enterprise in manufacturing by virtue of its global advantages in large-volume injections. As of May 2019, Cologne ranked second in the country in terms of the number of applications for injection consistency evaluation and base drug over-evaluation.




Chengda Pharmaceutical Co., Ltd.Founded in 1999. Located in the scenic Hangjiahu Plain-Jiashan Economic and Technological Development Zone (national level). The company has two production plants, No. 5 Hengshan Road and No. 36 Huanghe Road. It covers an area of 123,743 square meters and a construction area of 67,760 square meters. The company is a high-tech enterprise with a provincial research and development center.

The company mainly produces APIs, food additives, feed additives and antibiotics, anti-cancer, anti-virus and other series of pharmaceutical intermediates, and the products are sold to more than 30 countries and regions. The company's self-developed L-carnitine product won the title of "National Key New Product" and passed the US FDA on-site inspection with zero defects in March 2013.

In 2012, a medium was used for the cooling and heating cycle in the production of APIs. It has been very stable since its operation. It has completely solved the problems of corrosion, cooling rate and heating rate. Factors occur and safety is guaranteed.


Zhejiang Jiuzhou Pharmaceutical Co., Ltd.(Stock abbreviation: Jiuzhou Pharmaceutical; stock code: 603456) was established in 1998. Its predecessor was Huangshan County Dongshan MSG Factory, which was founded in 1973. It is a main business with specialty raw materials and is a large international pharmaceutical company. Listed pharmaceutical companies that provide CDMO one-stop service for new drugs are the world's leading manufacturers of carbamazepine, oxcarbazepine, ketoprofen and gliclazide bulk drugs, and their international market shares are among the highest in the world. The company has won the top 100 pharmaceutical companies in the national pharmaceutical industry, the national leading exporter of raw material medicines, the national high-tech enterprise, the national technology innovation demonstration enterprise, the top 100 pharmaceutical enterprises in China, the "three" pilot enterprises in Zhejiang Province, and the innovation leader in Zhejiang Province. Honors such as enterprises, "Jiuzhou" brand won "Zhejiang Export Famous Brand".

In 2009, the company had three refrigeration systems, all of which used the "ice refrigerant" refrigerant. The operation effect is very good, mainly reflected in the amount of consumption, the cooling effect is good, and it is not corrosive to metals. The system circulating fluid has been kept clear and transparent.


Zhejiang Huahai Pharmaceutical Co., Ltd.Founded in 1989, its predecessor was Linhai City Xunqiao Synthetic Chemical Factory. In January 2001, it was changed to Zhejiang Huahai Pharmaceutical Co., Ltd. as a whole. In March 2003, the company's stock was successfully listed on the Shanghai Stock Exchange. Zhejiang Huahai Pharmaceutical Co., Ltd. is a high-tech enterprise, a national innovative enterprise and a "five batch" key enterprise confirmed by the provincial government. It has an enterprise technology center and a post-doctoral scientific research station. "The title of the pharmaceutical company. From 2000 to 2008, it was listed as "Top Ten Enterprises in Zhejiang Pharmaceutical Industry" for nine consecutive years

In 2010, the system selected LM-4 glacial refrigerant, which has achieved good results so far, and has basically no corrosion to metals. The circulating fluid has been kept clear and transparent, saving a lot of system maintenance costs.


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